Methyl-paraoxon comparative inhibition kinetics for acetylcholinesterases from brain of neotropical fishes.

@article{Filho2004MethylparaoxonCI,
  title={Methyl-paraoxon comparative inhibition kinetics for acetylcholinesterases from brain of neotropical fishes.},
  author={Moacelio V Silva Filho and Manildo M. Oliveira and Jo{\~a}o B Salles and Vera L{\'u}cia Freire da Cunha Bastos and Vicente P. F. Cassano and Jayme da Cunha Bastos},
  journal={Toxicology letters},
  year={2004},
  volume={153 2},
  pages={247-54}
}
Acetylcholinesterase (AChE) sensitivity to the organophosphorus (OP) pesticide methyl-paraoxon was measured in fourteen species of Neotropical marine and freshwater fish found in the waters of Brazil. The rate constant for phosphorylation, kp, the dissociation constant, kd, the second order rate constant, ki, and the IC50 value were measured at 28 degrees C in pH 7.5 buffer for AChE extracted from brain. In addition, the substrate affinity constant, km, was measured with acetylthiocholine. The… CONTINUE READING

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