Methyl methacrylate toxicity in rat nasal epithelium: studies of the mechanism of action and comparisons between species.

@article{Mainwaring2001MethylMT,
  title={Methyl methacrylate toxicity in rat nasal epithelium: studies of the mechanism of action and comparisons between species.},
  author={Gareth Mainwaring and John R Foster and V. T. Lund and Trevor Herbert Green},
  journal={Toxicology},
  year={2001},
  volume={158 3},
  pages={
          109-18
        }
}
Female F344 rats exposed to 200 ppm methyl methacrylate for 6 h developed a lesion in the nasal olfactory epithelium which was characterised by degeneration and atrophy. The severity of the lesion was markedly reduced by pre-treatment of the rats with an intraperitoneal dose of 100 mg/kg bis-(p-nitrophenyl)phosphate, an inhibitor of carboxylesterase enzymes, thus demonstrating that the lesion is caused by the carboxylesterase mediated metabolism of methyl methacrylate to methacrylic acid, an… CONTINUE READING
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