Methyl jasmonate down-regulates survivin expression and sensitizes colon carcinoma cells towards TRAIL-induced cytotoxicity.

@article{Raviv2011MethylJD,
  title={Methyl jasmonate down-regulates survivin expression and sensitizes colon carcinoma cells towards TRAIL-induced cytotoxicity.},
  author={Zvi Raviv and Alona Zilberberg and Sivan Cohen and Dortit Reischer-Pelech and C. Horrix and Martin R Berger and Rina Rosin-Arbesfeld and Eliezer Flescher},
  journal={British journal of pharmacology},
  year={2011},
  volume={164 5},
  pages={1433-44}
}
BACKGROUND AND PURPOSE Methyl jasmonate (MJ) is a plant stress hormone with selective cytotoxic anti-cancer activities. The TNF-related apoptosis-inducing ligand (TRAIL) death pathway is an attractive target for cancer therapy. Although TRAIL receptors are specifically expressed in primary cancer cells and cancer cell lines, many types of cancer cells remain resistant to TRAIL-induced cytotoxicity. Here we have assessed a possible synergy between MJ and TRAIL cytotoxicity in colorectal cancer… CONTINUE READING
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