Methyl-beta-cyclodextrin and doxorubicin pharmacokinetics and tissue concentrations following bolus injection of these drugs alone or together in the rabbit.

@article{Grosse1999MethylbetacyclodextrinAD,
  title={Methyl-beta-cyclodextrin and doxorubicin pharmacokinetics and tissue concentrations following bolus injection of these drugs alone or together in the rabbit.},
  author={Pascal Grosse and Françoise Bressolle and P Rouanet and Jean M. Joulia and Fr{\'e}d{\'e}ric Pinguet},
  journal={International journal of pharmaceutics},
  year={1999},
  volume={180 2},
  pages={215-23}
}
The purpose of this work was to determine the pharmacokinetics and the tissue concentrations of methyl-beta-cyclodextrin (MEBCD) and doxorubicin (DOX) in rabbits following administration of MEBCD and DOX, alone or in combination. MEBCD (200 mg/kg) and DOX (1 mg/kg) were intravenously injected to white New Zealand rabbits and blood samples were obtained over a 48-h period after administration. After this period, administration was repeated and animals were killed 1, 2 or 4 h after injection… CONTINUE READING