Methyl-RNA: an evolutionary bridge between RNA and DNA?

  title={Methyl-RNA: an evolutionary bridge between RNA and DNA?},
  author={Anthony M. Poole and D. Penny and B Sj{\"o}berg},
  journal={Chemistry & biology},
  volume={7 12},
Given the apparent limitation of double-stranded RNA (dsRNA) genomes to about 30 kb, together with the complexity of DNA synthesis, it appears difficult for a dsRNA genome to encode all the information required before the transition from an RNA to a DNA genome. Ribonucleotide reductase itself, which synthesizes deoxyribonucleotides from ribonucleotides, requires complex protein radical chemistry, and RNA world genomes may have reached their limits of coding capacity well before such complex… CONTINUE READING