Methyl Donor-Deficient Diet during Development Can Affect Fear and Anxiety in Adulthood in C57BL/6J Mice

@inproceedings{Ishii2014MethylDD,
  title={Methyl Donor-Deficient Diet during Development Can Affect Fear and Anxiety in Adulthood in C57BL/6J Mice},
  author={Daisuke Ishii and Daisuke Matsuzawa and Shingo Matsuda and Haruna Tomizawa and Chihiro Sutoh and Eiji Shimizu},
  booktitle={PloS one},
  year={2014}
}
DNA methylation is one of the essential factors in the control of gene expression. Folic acid, methionine and choline (methyl donors)--all nutrients related to one-carbon metabolism--are known as important mediators of DNA methylation. A previous study has shown that long-term administration of a diet lacking in methyl donors caused global DNA hypermethylation in the brain (Pogribny et al., 2008). However, no study has investigated the effects of a diet lacking in methyl donors during the… CONTINUE READING
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