Methyl-CpG targeted recruitment of p300 reactivates tumor suppressor genes in human cancer cells.

@article{Fukushige2009MethylCpGTR,
  title={Methyl-CpG targeted recruitment of p300 reactivates tumor suppressor genes in human cancer cells.},
  author={Shinichi Fukushige and Emiko Kondo and Akira Horii},
  journal={Biochemical and biophysical research communications},
  year={2009},
  volume={379 4},
  pages={1021-6}
}
Aberrant hypermethylation of gene promoters is a major mechanism associated with inactivation of tumor suppressor genes (TSGs) in cancer. We have previously shown that the methyl-CpG targeted transcriptional activation (MeTA) that allows re-expression of TSGs in human cancer cells is accomplished by combining a methyl-CpG binding domain (MBD) with a NFkappaB transcriptional activation domain (AD), accompanied by histone H3K9/K14 acetylation. Herein we demonstrate that p300 histone… CONTINUE READING