Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression.

@article{Fujita2003MethylCpGBD,
  title={Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression.},
  author={Naoyuki Fujita and Sugiko Watanabe and Takaya Ichimura and Shu Tsuruzoe and Yoichi Shinkai and Makoto Tachibana and Tsutomu Chiba and Mitsuyoshi Nakao},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 26},
  pages={24132-8}
}
Cytosine methylation and posttranslational modifications of the amino termini of the core histones in the nucleosome provide epigenetic codes for genome regulation. In the nucleus, not only is the DNA methylated, but the methylated DNA is also interpreted by methyl-CpG binding domain (MBD) proteins. MBD1 possesses an MBD involved in mediating DNA methylation-dependent transcriptional repression. The MBD of MBD1 binds a symmetrically methylated CpG sequence, but the precise roles of this domain… CONTINUE READING
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