Methyl 3,4-dihydroxybenzoate protects primary cortical neurons against Aβ₂₅₋₃₅-induced neurotoxicity through mitochondria pathway.

Abstract

Amyloid-β peptides (Aβ), which can aggregate into oligomers or fibrils in neurons, play a critical role in the pathogenesis of Alzheimer's disease (AD). Methyl 3,4-dihydroxybenzoate (MDHB), a phenolic acid compound, has been reported to have antioxidative and neurotrophic effects. The present study investigated the neuroprotective effects of MDHB against A… (More)
DOI: 10.1002/jnr.23235

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@article{Zhou2013Methyl3P, title={Methyl 3,4-dihydroxybenzoate protects primary cortical neurons against Aβ₂₅₋₃₅-induced neurotoxicity through mitochondria pathway.}, author={Xiao-wen Zhou and Zheng Zhang and Chao-Fen Su and Ruo-Hua Lv and Xing Zhou and Liang Cai and Chen-Yu Wang and Li Yan and Wei Zhang and Huanmin Luo}, journal={Journal of neuroscience research}, year={2013}, volume={91 9}, pages={1215-25} }