Methoxylation of desazadesferrithiocin analogues: enhanced iron clearing efficiency.

@article{Bergeron2003MethoxylationOD,
  title={Methoxylation of desazadesferrithiocin analogues: enhanced iron clearing efficiency.},
  author={Raymond J. Bergeron and Jan Wiegand and James S. McManis and Joerg Bussenius and Richard E. Smith and William R. Weimar},
  journal={Journal of medicinal chemistry},
  year={2003},
  volume={46 8},
  pages={1470-7}
}
The impact of altering the octanol-water partition properties (log P) of analogues of desazadesferrithiocin, (S)-4,5-dihydro-2-(2-hydroxyphenyl)-4-methyl-4-thiazolecarboxylic acid, on the ligands' iron clearing properties is described. Increasing chelator lipophilicity can both substantially augment iron clearing efficiency in Cebus apella primates as well as alter the mode of iron excretion, favoring fecal over urinary output. The complications of iron overload are often associated with the… CONTINUE READING