Methoxyflurane in Clinical Use: A Comparison With Cyclopropane

@article{Kristoffersen1968MethoxyfluraneIC,
  title={Methoxyflurane in Clinical Use: A Comparison With Cyclopropane},
  author={M. B. Kristoffersen},
  journal={Anesthesia \& Analgesia},
  year={1968},
  volume={47},
  pages={616–622}
}
Methoxyflurane is generally considered a slow-acting agent, with prolonged induction and awakening times resulting from its high fat solubility and its low vapor pressure at rmm temperature. However, our clinical experiences with methoxyflurane in a 1/1 or 211 mixture of nitrous oxide-oxygen have shown that if a nonrebreathing system without much rubber tubing is used, induction time will be shorter than when a circle system is used, especially with higher degrees of rebreathing. 

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