Methoxyflurane Analgesia: A Clinical Appraisal and Detailed Description of Stage I in Man

@article{Reier1970MethoxyfluraneAA,
  title={Methoxyflurane Analgesia: A Clinical Appraisal and Detailed Description of Stage I in Man},
  author={Charles E. Reier},
  journal={Anesthesia \& Analgesia},
  year={1970},
  volume={49},
  pages={318–322}
}
  • C. E. Reier
  • Published 1 March 1970
  • Medicine
  • Anesthesia & Analgesia
N 1779, Sir Humphrey Davy discovered I the analgesic property of nitrous oxide during inhalation of the gas while suffering from a t0othache.l Since that time analgesia associated with subanesthetic concentrations has been reported for most anesthetic agents.z.8 Unfortunately, each of these agents has certain undesirable characteristics (explosiveness, neurotoxicity, unpleasant odor) which have limited its clinical use in this manner. 
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References

SHOWING 1-10 OF 26 REFERENCES
Alterations in response to somatic pain associated with anaesthesia. X: Further studies with inhalation agents.
TLDR
Hypotension was a common finding with this mixture of pethidine, chlorpromazine and promethazine and its severity and duration was such as to out-weigh any advantages it might have for use in premedication.
Di-ethyl ether analgesia: a detailed description of the first stage of ether anesthesia in man.
  • J. F. Artusio
  • Medicine
    The Journal of pharmacology and experimental therapeutics
  • 1954
TLDR
A specific electroencephalographic pattern for ether analgesia ( stage I— plane 3 ) has been defined and the stage of delirium is not seen, after the first stage of anesthesia has once been established, by the technique described.
ALTERATIONS IN RESPONSE TO SOMATIC PAIN ASSOCIATED WITH ANAESTHESIA IV. THE EFFECT OF SUB‐ANAESTHETIC CONCENTRATIONS OF INHALATION AGENTS
TLDR
The authors refer to analgesia as a state in which there is decreased appreciation of pain, while in the unconscious subject (where muscle relaxants have not been used) it can be demonstrated by absence or decreased response to a painful stimulus.
Ether analgesia during major surgery.
  • J. F. Artusio
  • Medicine
    Journal of the American Medical Association
  • 1955
TLDR
Firmly convinced that the analgesic state was most physiological, Gwathmey introduced synergistic analgesia in 1921, using a combination of ether in oil rectally and morphine and magnesium sulfate parenterally.
A CLINICAL EVALUATION OF METHOXYFLURANE IN MAN
TLDR
A CLINICAL EVALUATION of METHOXYFLURane in man and its application in anesthesiology shows promising results.
Minimum Alveolar Concentrations of Methoxyflurane, Halothane, Ether and Cyclopropane in Man: Correlation with Theories of Anesthesia
TLDR
MAC as a measure of anesthetic potency correlates better with Iipid solubility than with any other physical constant and should be considered when the primary site of anesthesia action within the brain is sought.
Clinical evaluation of methoxvflurane in obstetrical anaesthesia: A report on 500 cases
TLDR
Penthrane is at the moment experimenting with the use of Penthrane in Caesarean sections and present data show it to be a promising agent.
Succinylcholine and inhalation analgesia for major cardiac and pulmonic surgery.
TLDR
This method of anesthesia has been used in 253 operations on the chest, including 115 mitral commissurotomies and 22 circumferential mitral sutures, and has several advantages.
The Effects of Methoxyflurane on Ventilation in Man
TLDR
An estimate of MAC for methoxyflurane in this study was 0.17 per cent, which agrees with previous reports despite employment of different criteria, and change in slope of the carbon dioxide response curve decreased progressively with increasing depth of anesthesia.
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