Methoxyestradiols mediate the antimitogenic effects of estradiol on vascular smooth muscle cells via estrogen receptor-independent mechanisms.

@article{Dubey2000MethoxyestradiolsMT,
  title={Methoxyestradiols mediate the antimitogenic effects of estradiol on vascular smooth muscle cells via estrogen receptor-independent mechanisms.},
  author={Raghvendra K Dubey and Delbert G. Gillespie and Lefteris Zacharia and Marinella Rosselli and Kenneth Ray Korzekwa and J{\"u}rgen Fingerle and Edwin K Jackson},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={278 1},
  pages={
          27-33
        }
}
Estrogen receptors (ERs) are widely held to mediate the ability of 17 beta-estradiol (estradiol) to attenuate injury-induced proliferation of vascular smooth muscle cells (VSMCs) leading to vascular lesions. However, recent findings that estradiol prevents injury-induced vascular lesion formation in knock-out mice lacking either ER alpha or ER beta seriously challenge this concept. Here we report that the local metabolism of estradiol to methoxyestradiols, endogenous metabolites of estradiol… CONTINUE READING
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