Methoxychlor regulates rat uterine estrogen-induced protein.

  title={Methoxychlor regulates rat uterine estrogen-induced protein.},
  author={A. Cummings and J. L. Metcalf},
  journal={Toxicology and applied pharmacology},
  volume={130 1},
  • A. Cummings, J. L. Metcalf
  • Published 1995
  • Biology, Medicine
  • Toxicology and applied pharmacology
  • Methoxychlor (MXC), a proestrogenic pesticide, has adverse effects on fertility and uterine function in rodents. MXC is converted to an estrogenic substance, 2,2-bis-(p-hydroxyphenyl)-1,1,1-trichloroethane (HPTE), which binds to the estrogen receptor. We examined the similarities in mechanism between MXC (500 mg/kg) and estrogen (10 micrograms/rat) actions using the estrogen-induced protein, IP, also known as creatine kinase. Immature, female rats were treated with MXC or estradiol (E2… CONTINUE READING
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