Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse.

@article{Borgeest2002MethoxychlorMC,
  title={Methoxychlor may cause ovarian follicular atresia and proliferation of the ovarian epithelium in the mouse.},
  author={Christina Borgeest and Daniel A Symonds and Loretta P. Mayer and Patricia B. Hoyer and Jodi Anne Flaws},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2002},
  volume={68 2},
  pages={473-8}
}
Methoxychlor (MXC) is currently used to protect agricultural products from insects. Previous studies show that MXC adversely affects the ovary, but the target cells were not revealed by those studies. Therefore, the purpose of this study was to test the hypothesis that MXC induces ovarian changes by adversely affecting the antral follicles and the ovarian surface epithelium in the mouse. To test this hypothesis, cycling female CD-1 mice (39 days) were dosed with MXC (8, 16, or 32 mg/kg/day… CONTINUE READING
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