Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation.

@article{Schuh2005MethoxychlorIB,
  title={Methoxychlor inhibits brain mitochondrial respiration and increases hydrogen peroxide production and CREB phosphorylation.},
  author={Rosemary A. Schuh and Tibor Kristian and Rupesh K. Gupta and Jodi Anne Flaws and Gary Fiskum},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2005},
  volume={88 2},
  pages={
          495-504
        }
}
The organochlorine insecticide methoxychlor (mxc) is an established reproductive toxicant that affects other systems including the central nervous system (CNS), possibly by mechanisms involving oxidative stress. This study tested the hypothesis that mxc inhibits brain mitochondrial respiration, resulting in increased production of reactive oxygen species (ROS). Oxygen electrode measurements of mitochondrial respiration and Amplex Red measurements of H(2)O(2) production were performed with rat… CONTINUE READING

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