Methoxychlor as a model for environmental estrogens.

  title={Methoxychlor as a model for environmental estrogens.},
  author={A. Cummings},
  journal={Critical reviews in toxicology},
  volume={27 4},
  • A. Cummings
  • Published 1997
  • Biology, Medicine
  • Critical reviews in toxicology
  • Estrogens can have a variety of physiological effects, especially on the reproductive system. Chemicals with estrogenic activity that are present in the environment may thus be considered potentially hazardous to development and/or reproduction. Methoxychlor is one such chemical, a chlorinated hydrocarbon pesticide with proestrogenic activity. Metabolism of the chemical either in vivo or using liver microsomes produces 2,2-bis(p-hydroxyphenyl)- 1,1,1-trichloroethane (HPTE), the active… CONTINUE READING
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