Methoxychlor as a model for environmental estrogens.
@article{Cummings1997MethoxychlorAA, title={Methoxychlor as a model for environmental estrogens.}, author={A. Cummings}, journal={Critical reviews in toxicology}, year={1997}, volume={27 4}, pages={ 367-79 } }
Estrogens can have a variety of physiological effects, especially on the reproductive system. Chemicals with estrogenic activity that are present in the environment may thus be considered potentially hazardous to development and/or reproduction. Methoxychlor is one such chemical, a chlorinated hydrocarbon pesticide with proestrogenic activity. Metabolism of the chemical either in vivo or using liver microsomes produces 2,2-bis(p-hydroxyphenyl)- 1,1,1-trichloroethane (HPTE), the active… CONTINUE READING
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References
SHOWING 1-10 OF 69 REFERENCES
Role of hepatic monooxygenases in generating estrogenic metabolites from methoxychlor and from its identified contaminants.
- Chemistry, Medicine
- Molecular pharmacology
- 1985
- 67
Estrogenic activities of chlorinated hydrocarbons.
- Chemistry, Medicine
- Journal of toxicology and environmental health
- 1978
- 88
Environmentally persistent alkylphenolic compounds are estrogenic.
- Biology, Medicine
- Endocrinology
- 1994
- 1,369
- PDF
Methoxychlor regulates rat uterine estrogen-induced protein.
- Biology, Medicine
- Toxicology and applied pharmacology
- 1995
- 25
A novel in vitro method for demonstrating proestrogens. Metabolism of methoxychlor and o,p'DDT by liver microsomes in the presence of uteri and effects on intracellular distribution of estrogen receptors.
- Chemistry, Medicine
- Life sciences
- 1979
- 36
Purified methoxychlor stimulates the reproductive tract in immature female mice.
- Biology, Medicine
- Reproductive toxicology
- 1993
- 51
Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation.
- Chemistry, Medicine
- Biochemical pharmacology
- 1978
- 225
Effects of low subchronic doses of methoxychlor on the rat hypothalamic-pituitary reproductive axis.
- Biology, Medicine
- Toxicology and applied pharmacology
- 1986
- 86
Effects of pesticides and related compounds on steroid metabolism and function.
- Chemistry, Medicine
- CRC critical reviews in toxicology
- 1975
- 92
Methoxychlor affects the decidual cell response of the uterus but not other progestational parameters in female rats.
- Biology, Medicine
- Toxicology and applied pharmacology
- 1987
- 62