• DOI:10.1016/j.mehy.2012.07.002
Corpus ID: 22390568

Methoxetamine: from drug of abuse to rapid-acting antidepressant.

@article{Coppola2012MethoxetamineFD,
  title={Methoxetamine: from drug of abuse to rapid-acting antidepressant.},
  author={M. Coppola and R. Mondola},
  journal={Medical hypotheses},
  year={2012},
  volume={79 4},
  pages={
          504-7
        }
}

M. Coppola, R. Mondola

Published 2012

Medicine, Biology

Medical hypotheses

Methoxetamine is a dissociative anaesthetic showing pharmacodynamic similarities with its analogue ketamine, a medication with demonstrated rapid-acting antidepressant effects. Like ketamine and other arylcyclohexylamine compounds, methoxetamine is thought to be both a noncompetitive NMDA receptor antagonist and a dopamine reuptake inhibitor. Furthermore, it acts as an agonist at dopamine D2, serotonin 5HT2, muscarinic cholinergic, sigma-1, opioid mu and k receptors. The hypothesis is that… CONTINUE READING

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