Methotrexate reduces vaccine-specific immunoglobulin levels but not numbers of circulating antibody-producing B cells in rheumatoid arthritis after vaccination with a conjugate pneumococcal vaccine.

Abstract

BACKGROUND Treatment with methotrexate (MTX) in patients with rheumatoid arthritis (RA) leads to decreased total immunoglobulin (Ig) levels and impairs vaccine-specific IgG antibody levels following pneumococcal vaccination. The mechanisms by which MTX exerts these effects in RA are unknown. We aimed to evaluate whether MTX reduces vaccine-specific serum Ig… (More)
DOI: 10.1016/j.vaccine.2016.12.068

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Cite this paper

@article{Kapetanovic2017MethotrexateRV, title={Methotrexate reduces vaccine-specific immunoglobulin levels but not numbers of circulating antibody-producing B cells in rheumatoid arthritis after vaccination with a conjugate pneumococcal vaccine.}, author={Meliha Crnkic Kapetanovic and Johanna Nagel and Inger Nordstr{\"o}m and Tore Saxne and Pierre Geborek and Anna Rudin}, journal={Vaccine}, year={2017}, volume={35 6}, pages={903-908} }