Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying antirheumatic drugs for rheumatoid arthritis: abridged Cochrane systematic review and network meta-analysis.

@article{Hazlewood2016MethotrexateMA,
  title={Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying antirheumatic drugs for rheumatoid arthritis: abridged Cochrane systematic review and network meta-analysis.},
  author={Glen S Hazlewood and Cheryl Barnabe and George Tomlinson and Deborah A Marshall and Dan Devoe and Claire Bombardier},
  journal={BMJ},
  year={2016},
  volume={353},
  pages={i1777}
}
OBJECTIVE To compare methotrexate based disease modifying antirheumatic drug (DMARD) treatments for rheumatoid arthritis in patients naive to or with an inadequate response to methotrexate. DESIGN Systematic review and Bayesian random effects network meta-analysis of trials assessing methotrexate used alone or in combination with other conventional synthetic DMARDs, biologic drugs, or tofacitinib in adult patients with rheumatoid arthritis. DATA SOURCES Trials were identified from Medline… CONTINUE READING
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ORAL Standard Investigators . Tofacitinib or adalimumab versus placebo in rheumatoid arthritis

  • RF vanVollenhoven, R Fleischmann, S Cohen
  • N Engl J Med
  • 2015

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