Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation

@article{Thornton2016MethotrexatemediatedAO,
  title={Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation},
  author={Catherine Clare Thornton and Fahad Al-Rashed and Damien Calay and Graeme M. Birdsey and Andrea Bauer and Hayley Mylroie and Bernard J. Morley and Anna M. Randi and Dorian O. Haskard and J. J. Boyle and Justin C. Mason},
  journal={Annals of the Rheumatic Diseases},
  year={2016},
  volume={75},
  pages={439 - 448}
}
Aims Premature cardiovascular events complicate chronic inflammatory conditions. Low-dose weekly methotrexate (MTX), the most widely used disease-modifying drug for rheumatoid arthritis (RA), reduces disease-associated cardiovascular mortality. MTX increases intracellular accumulation of adenosine monophosphate (AMP) and 5-aminoimidazole-4-carboxamide ribonucleotide which activates AMP-activated protein kinase (AMPK). We hypothesised that MTX specifically protects the vascular endothelium… Expand
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