Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors

@article{Kanagawa2015MethotrexateIO,
  title={Methotrexate inhibits osteoclastogenesis by decreasing RANKL-induced calcium influx into osteoclast progenitors},
  author={Hiroya Kanagawa and Ritsuko Masuyama and Mayu Morita and Yuiko Sato and Yasuo Niki and Tami Kobayashi and Eri Katsuyama and Atsuhiro Fujie and W. D. Hao and Toshimi Tando and Ryuichi Watanabe and Kana Miyamoto and Hideo Morioka and Morio Matsumoto and Yoshiaki Toyama and Hideyuki Saya and Takeshi Miyamoto},
  journal={Journal of Bone and Mineral Metabolism},
  year={2015},
  volume={34},
  pages={526-531}
}
The increasing number of osteoporosis patients is a pressing issue worldwide. Osteoporosis frequently causes fragility fractures, limiting activities of daily life and increasing mortality. Many osteoporosis patients take numerous medicines due to other health issues; thus, it would be preferable if a single medicine could ameliorate osteoporosis and other conditions. Here, we screened 96 randomly selected drugs targeting various diseases for their ability to inhibit differentiation of… CONTINUE READING