Methotrexate induction of human sulfotransferases in Hep G2 and Caco‐2 cells

@article{Chen2005MethotrexateIO,
  title={Methotrexate induction of human sulfotransferases in Hep G2 and Caco‐2 cells},
  author={Xinrong Chen and Sharon M Baker and Guangping Chen},
  journal={Journal of Applied Toxicology},
  year={2005},
  volume={25}
}
Methotrexate (MTX) was the first antifolate drug developed for the treatment of cancer. It is also effective in treating inflammatory and autoimmune diseases. Sulfotransferases are phase II drug‐metabolizing enzymes and their induction by hormones and endogenous molecules is relatively well known, although xenobiotic drug induction of sulfotransferases has not been well studied. In the present investigation, MTX is shown to be a xenobiotic inducer of human sulfotransferases in transformed human… Expand
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TLDR
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Identification of the Human SULT Enzymes Involved in the Metabolism of Rotigotine
TLDR
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