Methotrexate induces interleukin-8 production by human bronchial and alveolar epithelial cells.

@article{Yamauchi2004MethotrexateII,
  title={Methotrexate induces interleukin-8 production by human bronchial and alveolar epithelial cells.},
  author={Yasuhiro Yamauchi and Hitoshi Okazaki and Masashi Desaki and Tadashi Kohyama and Shin Kawasaki and Kazuhiko Yamamoto and Hajime Takizawa},
  journal={Clinical science},
  year={2004},
  volume={106 6},
  pages={619-25}
}
Methotrexate (MTX) has been widely used for the treatment of a variety of tumours as well as for inflammatory diseases. MTX-induced pneumonitis has been a serious unpredictable side effect of the treatment and an important clinical problem. However, its mechanism remains largely unclear. Possible causes include allergic, cytotoxic or immunologic reactions to this agent. To elucidate the proinflammatory mechanism of MTX-induced pneumonitis, we evaluated the effect of MTX on the production of IL… CONTINUE READING