Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.

@article{Bhojwani2014MethotrexateinducedNA,
  title={Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.},
  author={D. Bhojwani and N. Sabin and D. Pei and J. Yang and R. B. Khan and J. Panetta and K. Krull and H. Inaba and J. Rubnitz and M. Metzger and S. Howard and R. Ribeiro and C. Cheng and W. Reddick and S. Jeha and J. Sandlund and W. Evans and C. Pui and M. Relling},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2014},
  volume={32 9},
  pages={
          949-59
        }
}
  • D. Bhojwani, N. Sabin, +16 authors M. Relling
  • Published 2014
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
PURPOSE Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. [...] Key MethodPATIENTS AND METHODS Prospective brain magnetic resonance imaging was performed at four time points for 369 children with ALL treated in a contemporary study that included five courses of high-dose MTX and 13 to 25 doses of triple intrathecal therapy.Expand
161 Citations

Paper Mentions

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