Methotrexate-induced Changes in Rat Parotid and Submandibular Gland Function

  title={Methotrexate-induced Changes in Rat Parotid and Submandibular Gland Function},
  author={R K McBride and C Harper and Ivens A. Siegel},
  journal={Journal of Dental Research},
  pages={1445 - 1448}
Methotrexate (MTX) was injected intraperitoneally at a dose of 15 mglkg into adult rats daily for three consecutive days. When compared with saline-injected, ad libitum-fed rats or pair-fed saline-injected rats, MTX decreased unstimulated parotid gland weight, RNA content, and amylase content. RNA content was also decreased in submandibular glands. The pqrotid and submandibular gland outputs of sodium and chloride, but not that of potassium, were decreased following MTX injection. Ductal… 

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