Corpus ID: 26810229

Methotrexate increases glycogenolysis in the intact rat liver.

@article{Oliveira1986MethotrexateIG,
  title={Methotrexate increases glycogenolysis in the intact rat liver.},
  author={M. B. de Oliveira and E. L. Ishii and N. Yamamoto and A. Bracht and A. D. Campello and M. Kluppel},
  journal={Research communications in chemical pathology and pharmacology},
  year={1986},
  volume={53 2},
  pages={
          173-81
        }
}

M. B. de Oliveira, E. L. Ishii, +4 authors A. Bracht

Published 1986

Biology, Medicine

Research communications in chemical pathology and pharmacology

View on PubMed

Save to Library

Create Alert

Cite

Launch Research Feed

The effect of methotrexate, an anti-cancer drug, on carbohydrate metabolism in the isolated perfused rat liver was investigated. Glucose release from endogenous glycogen (glycogenolysis) is strongly activated by methotrexate. The phenomenon shows a well defined concentration dependence: 100% activation occurs at 2.2 X 10(-4) M. Glycolysis and oxygen consumption are only slightly affected.