Corpus ID: 26810229

Methotrexate increases glycogenolysis in the intact rat liver.

  title={Methotrexate increases glycogenolysis in the intact rat liver.},
  author={M. B. de Oliveira and E. Ishii and N. Yamamoto and A. Bracht and A. D. Campello and M. Kluppel},
  journal={Research communications in chemical pathology and pharmacology},
  volume={53 2},
  • M. B. de Oliveira, E. Ishii, +4 authors A. Bracht
  • Published 1986
  • Biology, Medicine
  • Research communications in chemical pathology and pharmacology
  • The effect of methotrexate, an anti-cancer drug, on carbohydrate metabolism in the isolated perfused rat liver was investigated. Glucose release from endogenous glycogen (glycogenolysis) is strongly activated by methotrexate. The phenomenon shows a well defined concentration dependence: 100% activation occurs at 2.2 X 10(-4) M. Glycolysis and oxygen consumption are only slightly affected. 
    10 Citations

    Topics from this paper

    Effects of methotrexate on calcium flux in rat liver mitochondria, microsomes and plasma membrane vesicles.
    • 5
    Biochemical effects of methotrexate in isolated hepatocytes in relation to its steatogenic activity.
    • 4
    Changes in calcium fluxes in mitochondria, microsomes, and plasma membrane vesicles of livers from monosodium L-glutamate-obese rats.
    • 2
    Symptomatic hypoglycemia: An unusual side effect of oral purine analogues for treatment of ALL
    • 13
    Can pretreatment serum calcium level predict the efficacy of methotrexate in the treatment of severe plaque psoriasis?
    • 5