Corpus ID: 26810229

Methotrexate increases glycogenolysis in the intact rat liver.

@article{Oliveira1986MethotrexateIG,
  title={Methotrexate increases glycogenolysis in the intact rat liver.},
  author={M. B. de Oliveira and E. Ishii and N. Yamamoto and A. Bracht and A. D. Campello and M. Kluppel},
  journal={Research communications in chemical pathology and pharmacology},
  year={1986},
  volume={53 2},
  pages={
          173-81
        }
}

M. B. de Oliveira, E. Ishii, +4 authors A. Bracht

Published 1986

Biology, Medicine

Research communications in chemical pathology and pharmacology

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The effect of methotrexate, an anti-cancer drug, on carbohydrate metabolism in the isolated perfused rat liver was investigated. Glucose release from endogenous glycogen (glycogenolysis) is strongly activated by methotrexate. The phenomenon shows a well defined concentration dependence: 100% activation occurs at 2.2 X 10(-4) M. Glycolysis and oxygen consumption are only slightly affected.