Methotrexate increases glycogenolysis in the intact rat liver.
@article{Oliveira1986MethotrexateIG, title={Methotrexate increases glycogenolysis in the intact rat liver.}, author={M. B. de Oliveira and E. L. Ishii and N. Yamamoto and A. Bracht and A. D. Campello and M. Kluppel}, journal={Research communications in chemical pathology and pharmacology}, year={1986}, volume={53 2}, pages={ 173-81 } }
The effect of methotrexate, an anti-cancer drug, on carbohydrate metabolism in the isolated perfused rat liver was investigated. Glucose release from endogenous glycogen (glycogenolysis) is strongly activated by methotrexate. The phenomenon shows a well defined concentration dependence: 100% activation occurs at 2.2 X 10(-4) M. Glycolysis and oxygen consumption are only slightly affected.
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