Methotrexate in combination with infliximab is no more effective than infliximab alone in patients with Crohn's disease.

@article{Feagan2014MethotrexateIC,
  title={Methotrexate in combination with infliximab is no more effective than infliximab alone in patients with Crohn's disease.},
  author={Brian G Feagan and J. W. McDonald and Remo Panaccione and Robert A Enns and Charles N Bernstein and Terry P Ponich and Raymond Bourdages and Donald G Macintosh and Chrystian Dallaire and Albert Cohen and Richard N Fedorak and Pierre Par{\'e} and Alain Bitton and Fred G Saibil and Frank H Anderson and Allan Donner and Cindy J. Wong and Guang Yong Zou and Margaret K. Vandervoort and Marybeth Hopkins and Gordon R. Greenberg},
  journal={Gastroenterology},
  year={2014},
  volume={146 3},
  pages={681-688.e1}
}
BACKGROUND & AIMS Methotrexate and infliximab are effective therapies for Crohn's disease (CD). In the combination of maintenance methotrexate-infliximab trial, we evaluated the potential superiority of combination therapy over infliximab alone. METHODS In a 50-week, double-blind, placebo-controlled trial, we compared methotrexate and infliximab with infliximab alone in 126 patients with CD who had initiated prednisone induction therapy (15-40 mg/day) within the preceding 6 weeks. Patients… CONTINUE READING
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