Methotrexate in Rheumatoid Arthritis

  title={Methotrexate in Rheumatoid Arthritis},
  author={B. Bannwarth and L. Labat and Y. Moride and T. Schaeverbeke},
  • B. Bannwarth, L. Labat, +1 author T. Schaeverbeke
  • Published 2012
  • Medicine
  • Drugs
  • SummaryMethotrexate has been approved for the treatment of refractory rheumatoid arthritis by several regulatory agencies, including the Food and Drug Administration. The tendency is now to prescribe it at earlier stages of the disease.Methotrexate is a well known antifolate. Its exact mechanism of action in rheumatoid arthritis remains uncertain. The polyglutamated derivatives of methotrexate are potent inhibitors of various enzymes, including dihydrofolate reductase and 5-aminoimidazole-4… CONTINUE READING
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