Methotrexate in Crohn's disease: long-term efficacy and toxicity

Abstract

OBJECTIVE:A 16-wk, placebo-controlled trial has recently shown weekly low-dose methotrexate to be an effective treatment for patients with chronically active Crohn's disease. The long-term efficacy and safety of this antimetabolite drug, however, are not yet well established and are assessed in this study.METHODS:A total of 49 patients with Crohn's disease… (More)
DOI: 10.1111/j.1572-0241.2000.02190.x

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