Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARγ and Nrf2: Protective effect of 18β-Glycyrrhetinic acid.
@article{Mahmoud2017MethotrexateHI, title={Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPAR$\gamma$ and Nrf2: Protective effect of 18$\beta$-Glycyrrhetinic acid.}, author={Ayman Moawad Mahmoud and Omnia E. Hussein and Walaa G. Hozayen and Sanaa M. Abd El-Twab}, journal={Chemico-biological interactions}, year={2017}, volume={270}, pages={ 59-72 } }
Figures and Tables from this paper
109 Citations
Chicoric acid prevents methotrexate hepatotoxicity via attenuation of oxidative stress and inflammation and up-regulation of PPARγ and Nrf2/HO-1 signaling
- Biology, MedicineEnvironmental Science and Pollution Research
- 2020
CA prevented oxidative stress, inflammation, and liver injury induced by MTX by activating Nrf2 /HO-1 signaling and PPARγ and inhibited apoptosis in MTX-administered rats.
Ferulic acid prevents oxidative stress, inflammation, and liver injury via upregulation of Nrf2/HO-1 signaling in methotrexate-induced rats
- Medicine, BiologyEnvironmental Science and Pollution Research
- 2019
Ferulic acid prevented MTX hepatotoxicity by activating Nrf2/HO-1 signaling and PPARγ, and attenuating oxidative stress, inflammation, and cell death, and prevented all histological alterations, ameliorated liver function markers, and boosted antioxidants in MTX-induced rats.
Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPARγ, and suppressing oxidative stress and apoptosis in rats.
- Medicine, BiologyBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- 2017
Alpha lipoic acid exerts antioxidant effect via Nrf2/HO-1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats.
- Medicine, BiologyBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
- 2018
Ferulic acid protects against methotrexate nephrotoxicity via activation of Nrf2/ARE/HO-1 signaling and PPARγ, and suppression of NF-κB/NLRP3 inflammasome axis.
- Medicine, BiologyFood & function
- 2019
Drug-induced nephrotoxicity contributes to acute kidney injury (AKI) and represents a major problem in the clinical setting. We investigated the possible involvement of NLRP3 inflammasome activation…
Human placental extract ameliorates methotrexate-induced hepatotoxicity in rats via regulating antioxidative and anti-inflammatory responses
- Biology, MedicineCancer Chemotherapy and Pharmacology
- 2021
HPE has the ability to ameliorate methotrexate-induced liver injury in rats by mechanisms that include boosting antioxidative responses and down-regulating MDA and pro-inflammatory cytokine production.
Galangin mitigates oxidative stress, inflammation, and apoptosis in a rat model of methotrexate hepatotoxicity
- Biology, MedicineEnvironmental Science and Pollution Research
- 2021
Gal possesses a hepatoprotective effect mediated by attenuating oxidative damage, inflammation, and apoptosis in rats, which relieved liver injury, ameliorated liver function, oxidative stress, and inflammation markers, and increased antioxidants in MTX-treated rats.
Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats
- Biology, MedicineDARU Journal of Pharmaceutical Sciences
- 2019
The clinical application of methotrexate (MTX), an efficacious cytotoxic drug, is restricted due to its associated liver toxicity. Ellagic acid (EA), a natural polyphenol, possesses hepatoprotective,…
Activation of pCREB/Nrf-2 signaling mediates re-positioning of liraglutide as hepato-protective for methotrexate -induced liver injury (MILI).
- Biology, MedicineFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association
- 2019
Punicalagin Protects against the Development of Methotrexate-Induced Hepatotoxicity in Mice via Activating Nrf2 Signaling and Decreasing Oxidative Stress, Inflammation, and Cell Death
- Biology, MedicineInternational journal of molecular sciences
- 2022
PU inhibits oxidative damage, inflammation, and apoptosis and upregulates Nrf2 in the liver of MTX-induced mice, suggesting that PU may have great therapeutic potential for the prevention of methotrexate-induced hepatotoxicity.
References
SHOWING 1-10 OF 90 REFERENCES
18β-Glycyrrhetinic acid protects against methotrexate-induced kidney injury by up-regulating the Nrf2/ARE/HO-1 pathway and endogenous antioxidants
- Medicine, ChemistryRenal failure
- 2016
Findings make 18β-GA candidate as a potent agent in preventing MTX-induced kidney injury with possible mechanisms of attenuating oxidative stress and inflammation through up-regulating the Nrf2/ARE signaling.
Pomegranate reverses methotrexate-induced oxidative stress and apoptosis in hepatocytes by modulating Nrf2-NF-κB pathways.
- Biology, MedicineThe Journal of nutritional biochemistry
- 2013
Hesperidin protects against cyclophosphamide-induced hepatotoxicity by upregulation of PPARγ and abrogation of oxidative stress and inflammation.
- Biology, MedicineCanadian journal of physiology and pharmacology
- 2014
The study suggests that hesperidin exerts its protective effect against CYP-induced hepatotoxicity through upregulation of hepatic PPARγ expression and abrogation of inflammation and oxidative stress.
The Protective Effect of Glycyrrhetinic Acid on Carbon Tetrachloride-Induced Chronic Liver Fibrosis in Mice via Upregulation of Nrf2
- Biology, ChemistryPloS one
- 2013
Results suggested that GA can protect the liver from oxidative stress in mice, presumably through activating the nuclear translocation of Nrf2, enhancing the expression of its target genes and increasing the activity of the antioxidant enzymes.
Gamma-Glutamylcysteine Ethyl Ester Protects against Cyclophosphamide-Induced Liver Injury and Hematologic Alterations via Upregulation of PPARγ and Attenuation of Oxidative Stress, Inflammation, and Apoptosis
- Biology, MedicineOxidative medicine and cellular longevity
- 2016
Pretreatment with GCEE protected against CP-induced hepatotoxicity, possibly by activating PPARγ, preventing GSH depletion, and attenuating oxidative stress, inflammation, and apoptosis.
Berberine mitigates cyclophosphamide-induced hepatotoxicity by modulating antioxidant status and inflammatory cytokines
- Biology, MedicineJournal of Cancer Research and Clinical Oncology
- 2014
Berberine showed a marked hepatoprotective effect against CP-induced hepatotoxicity through alleviation of the elevated serum marker enzymes in addition to its antioxidant and anti-inflammatory efficacies.
Mechanisms of Thymoquinone Hepatorenal Protection in Methotrexate-Induced Toxicity in Rats
- Medicine, BiologyMediators of inflammation
- 2015
Using TQ concurrently with MTX restored kidney and liver functions, as well as their normal histology, and TQ may be beneficial adjuvant that confers hepatorenal protection to MTX toxicity via antioxidant, antinitrosative, anti-inflammatory, and antiapoptotic mechanisms.
Protective Effects of Glycyrrhizic Acid and 18β-Glycyrrhetinic Acid against Cisplatin-Induced Nephrotoxicity in BALB/c Mice.
- Biology, ChemistryJournal of agricultural and food chemistry
- 2015
Oral administration of GA or 18βGA significantly reduced CP-induced increases in the levels of blood urea nitrogen, creatinine, and lactate dehydrogenase, and it was demonstrated that GA and 18 βGA rendered renal cells resistant toCP-induced HMGB1 cytoplasmic translocation and release.
Peroxisome Proliferator Activator Receptor (PPAR)-γ Ligand, but Not PPAR-α, Ameliorates Cyclophosphamide-Induced Oxidative Stress and Inflammation in Rat Liver
- Biology, MedicinePPAR research
- 2014
Activation of PPAR-γ, but not PPar-α, conferred protection against CP-induced hepatotoxicity, via activation of antioxidant and anti-inflammatory mechanisms, and may serve as supplement during CP chemotherapy.
Neuroprotective effects of glycyrrhizic acid and 18beta-glycyrrhetinic acid in PC12 cells via modulation of the PI3K/Akt pathway.
- BiologyJournal of agricultural and food chemistry
- 2009
The results suggest that GA may protect PC12 cells from ischemic injury via modulation of the intracellular antioxidant system and mitochondria-induced apoptosis and suggest that the cytotoxicity of 6-OHDA may influence the mitochondrial Bax/Bcl-2 ratio without altering the expression of Bax.