Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPARγ and Nrf2: Protective effect of 18β-Glycyrrhetinic acid.

@article{Mahmoud2017MethotrexateHI,
  title={Methotrexate hepatotoxicity is associated with oxidative stress, and down-regulation of PPAR$\gamma$ and Nrf2: Protective effect of 18$\beta$-Glycyrrhetinic acid.},
  author={Ayman M. Mahmoud and Omnia E. Hussein and Walaa G. Hozayen and Sanaa M Abd El-Twab},
  journal={Chemico-biological interactions},
  year={2017},
  volume={270},
  pages={
          59-72
        }
}
18β-glycyrrhetinic acid (18β-GA) is a bioactive component of licorice with promising hepatoprotective activity. However, its protective mechanism on methotrexate (MTX) hepatotoxicity in not well defined. We investigated the hepatoprotective effect of 18β-GA, pointing to the role of peroxisome proliferator activated receptor gamma (PPARγ) and the redox-sensitive nuclear factor erythroid 2-related factor 2 (Nrf2). Wistar rats were orally administered 18β-GA (50 and 100 mg/kg) 7 days either before… 
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