Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators.

@article{Feagan1995MethotrexateFT,
  title={Methotrexate for the treatment of Crohn's disease. The North American Crohn's Study Group Investigators.},
  author={Brian G Feagan and Justine Rochon and Richard N Fedorak and Elizabeth Jan Irvine and Gillian M. Wild and LloydR. Sutherland and A. Hillary Steinhart and Gordon R. Greenberg and Robyn Gillies and M. Gene Hopkins},
  journal={The New England journal of medicine},
  year={1995},
  volume={332 5},
  pages={
          292-7
        }
}
BACKGROUND Although corticosteroids are highly effective in improving symptoms of Crohn's disease, they may have substantial toxicity. In some patients, attempts to discontinue corticosteroids are unsuccessful. METHODS We conducted a double-blind, placebo-controlled multicenter study of weekly injections of methotrexate in patients who had chronically active Crohn's disease despite a minimum of three months of prednisone therapy. Patients were randomly assigned to treatment with intramuscular… CONTINUE READING

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