Methotrexate for high-grade osteosarcoma in children and young adults.

@article{Dalen2011MethotrexateFH,
  title={Methotrexate for high-grade osteosarcoma in children and young adults.},
  author={E. C. van Dalen and Jorrit W van As and B. de Camargo},
  journal={The Cochrane database of systematic reviews},
  year={2011},
  volume={5},
  pages={
          CD006325
        }
}
  • E. C. van Dalen, Jorrit W van As, B. de Camargo
  • Published 2011
  • Medicine
  • The Cochrane database of systematic reviews
  • BACKGROUND The majority of the currently used treatment protocols for osteosarcoma are based on a combination of doxorubicin, cisplatin, methotrexate (MTX) and/or ifosfamide, of which MTX seems to be one of the most active drugs. However, in the literature, this has not been unambiguously proven. OBJECTIVES To compare the effectiveness of treatment including MTX with treatment without MTX for children and young adults (up to 21 years) with primary high-grade osteosarcoma. SEARCH STRATEGY We… CONTINUE READING
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