Methotrexate enhances 3T3-L1 adipocytes hypertrophy

  title={Methotrexate enhances 3T3-L1 adipocytes hypertrophy},
  author={Cl{\'a}udia Marques and Diana Teixeira and Ana Cunha and Manuela Meireles and Diogo Pestana and Elisa Keating and Conceiç{\~a}o Calhau and Ros{\'a}rio Monteiro and Ana Faria},
  journal={Cell Biology and Toxicology},
Methotrexate (MTX) is broadly used in the treatment of chronic inflammatory diseases such as rheumatoid arthritis (RA). The prevalence of metabolic syndrome (MeS) in patients with this condition is relatively high. Given the importance of adipose tissue in the development of obesity metabolic complications, this study aimed to investigate the effect of methotrexate on preadipocyte proliferation, adipogenesis, and glucose uptake by adipocytes. 3T3-L1 preadipocytes proliferation was evaluated by… CONTINUE READING
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