Methotrexate does not interfere with an appetitive Pavlovian conditioning task in Sprague-Dawley rats.

Abstract

There has been considerable interest in developing an animal model of the neuropsychological toxicity of chemotherapeutic agents used in the treatment of patients with cancer, especially children, since these agents often cause significant, long-term neuropsychological deficits. Yanovski, Packer, Levine, Davidson, Micalizzi, D'Angio (13) recently proposed… (More)

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