Methotrexate causes apoptosis in postmitotic endothelial cells.

  title={Methotrexate causes apoptosis in postmitotic endothelial cells.},
  author={Carrie J. Merkle and Ida M Ki Moore and B S Penton and Bonny J Torres and R K Cueny and Richard C. Schaeffer and David W. Montgomery},
  journal={Biological research for nursing},
  volume={2 1},
Methotrexate (MTX) is a commonly used chemotherapy agent for a variety of cancers. However, therapeutic levels are associated with numerous untoward effects such as central nervous system damage in children with acute lymphoblastic leukemia. The purpose of this study was to determine if MTX caused injury to endothelial cells using cultured bovine pulmonary artery endothelial cells as a model. Light microscopy showed gaps between cells and reduced numbers of endothelial cells after exposure to… CONTINUE READING

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