Methotrexate bioavailability after oral and intramuscular administration in children.

  title={Methotrexate bioavailability after oral and intramuscular administration in children.},
  author={Mary E Teresi and William R. Crom and K. Eugene Choi and Joseph Mirro and William E. Evans},
  journal={The Journal of pediatrics},
  volume={110 5},
Although methotrexate is one of the most commonly used drugs for maintenance therapy in childhood acute lymphocytic leukemia (ALL), its oral absorption is highly variable and its intramuscular bioavailability at dosages used for ALL therapy has not been assessed in children. We therefore determined the absolute bioavailability of orally and intramuscularly administered methotrexate in 12 pediatric patients receiving 13 to 120 mg/m2 methotrexate every week as maintenance therapy for ALL. Mean… CONTINUE READING

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