Methotrexate and corticosteroid therapy for pediatric localized scleroderma.

  title={Methotrexate and corticosteroid therapy for pediatric localized scleroderma.},
  author={Yosef Uziel and Brian Michael Feldman and Bernice R. Krafchik and Rae S. M. Yeung and Ronald M. Laxer},
  journal={The Journal of pediatrics},
  volume={136 1},
INTRODUCTION Localized scleroderma (LS) can cause permanent disability, and there is no universally accepted effective treatment. Methotrexate (MTX) has been shown to be effective in the treatment of systemic sclerosis. OBJECTIVES To determine the efficacy and tolerability of MTX and corticosteroid therapy in patients with LS. METHODS MTX, 0.3 to 0.6 mg/kg per week, was given to 10 patients (6 girls, 4 boys; mean age, 6.8 years; mean disease duration before starting treatment, 4 years) with… CONTINUE READING

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