Methotrexate and 5-aminoimidazole-4-carboxamide riboside exert synergistic anticancer action against human breast cancer and hepatocellular carcinoma

@inproceedings{Cheng2013MethotrexateA5,
  title={Methotrexate and 5-aminoimidazole-4-carboxamide riboside exert synergistic anticancer action against human breast cancer and hepatocellular carcinoma},
  author={Xiaoliang Cheng and Tian-yan Zhou and Bo Li and Meng-yao Li and Liang Li and Zai-quan Li and Wei X Lu},
  booktitle={Acta Pharmacologica Sinica},
  year={2013}
}
Aim:To investigate the influences of methotrexate (MTX) on the anticancer actions and pharmacokinetics of 5-aminoimidazole-4-carboxamide riboside (AICA riboside) in human breast cancer and hepatocellular carcinoma.Methods:Human breast cancer cell line MCF-7 and human hepatocellular carcinoma cell line HepG2 were examined. The cell proliferation was assessed using a sulforhodamine B assay. Western blotting and radioactivity assays were used to analyze the phosphorylation of AMPK. The DNA… CONTINUE READING
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