Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes

  title={Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes},
  author={G. Russo and L. Minutoli and A. Bitto and D. Altavilla and Eugenio Alessi and A. Giandalia and E. Romeo and Maria Francesca Stagno and F. Squadrito and D. Cucinotta and J. Selhub},
  journal={Journal of Nutrition and Metabolism},
  • G. Russo, L. Minutoli, +8 authors J. Selhub
  • Published 2012
  • Medicine
  • Journal of Nutrition and Metabolism
  • Long-term administration of 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) mimics the effects of endurance exercise by activating AMP kinase and by increasing skeletal muscle expression of GLUT4 glucose transporter. AICAR is an intermediate in the purine de novo synthesis, and its tissue concentrations can be increased, in vivo, by low doses of methotrexate (MTX) through the inhibition of the enzyme AICAR transformylase. We report here the first evidence that, in experimental type 2… CONTINUE READING
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