Methotrexate Associated Renal Impairment Is Related to Delayed Elimination of High-Dose Methotrexate

  title={Methotrexate Associated Renal Impairment Is Related to Delayed Elimination of High-Dose Methotrexate},
  author={Shi-long Yang and Fen-ying Zhao and Hua Song and Di-Ying Shen and Xiaojun Xu},
Although Methotrexate (MTX) is an effective drug for the treatment of acute lymphoblastic leukemia (ALL), the toxicity remains a significant problem. In this prospective study, fifty-four patients with ALL were enrolled. 3 g or 5 g MTX/m(2) was administered over 24 hours. Serum MTX concentrations were determined in 24, 48, and 96 hours after MTX infusion. Serum creatinine concentrations and creatinine clearance rate (CCR) were determined before and 24 and 48 hours after MTX infusion. A total of… CONTINUE READING


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