Methods to identify and characterize inhibitors of bacterial RNA polymerase.

Abstract

RNA polymerase is essential to the viability of bacteria in all phases of growth and development and is a proven chemotherapeutic target as the cellular target of the rifamycin class of antibiotics. However, despite the characterization of multiple different classes of natural products that selectively target bacterial RNA polymerase, and the identification… (More)
DOI: 10.1007/978-1-59745-246-5_4

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