Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations.

  title={Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations.},
  author={William Beck and Thomas M. Grogan and Cheryl L. Willman and Carlos Cordon-Cardo and David M. Parham and John Frank Kuttesch and Michael Andreeff and Susan E Bates and C{\'e}dric B{\'e}rard and James M. Boyett and Nathalie Brophy and Henk J. Broxterman and Helen Shuk-ying Chan and William S Dalton and Manfred Dietel and Antonio Tito Fojo and Randy D. Gascoyne and Deanna Head and Peter James Houghton and Deo Kumar Srivastava and Manfred Lehnert and C P Leith and E Paietta and Zlatko P. Pavelic and Rachel Weinstein},
  journal={Cancer research},
  volume={56 13},
Multidrug resistance (MDR), especially that associated with overexpression of MDR1 and its product, P-glycoprotein (Pgp), is thought to play a role in the outcome of therapy for some human tumors; however, a consensus conclusion has been difficult to reach, owing to the variable results published by different laboratories. Many factors appear to influence the detection of Pgp in clinical specimens, including its low and heterogeneous expression; conflicting definitions of detection end points… CONTINUE READING


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