# Methods to calculate uncertainty in the estimated overall effect size from a random‐effects meta‐analysis

@article{Veroniki2018MethodsTC, title={Methods to calculate uncertainty in the estimated overall effect size from a random‐effects meta‐analysis}, author={Areti Angeliki Veroniki and Dan Jackson and Ralf Bender and Oliver Kuss and Dean Langan and Julian P. T. Higgins and Guido Knapp and Georgia Salanti}, journal={Research Synthesis Methods}, year={2018}, volume={10}, pages={23 - 43} }

Meta‐analyses are an important tool within systematic reviews to estimate the overall effect size and its confidence interval for an outcome of interest. If heterogeneity between the results of the relevant studies is anticipated, then a random‐effects model is often preferred for analysis. In this model, a prediction interval for the true effect in a new study also provides additional useful information. However, the DerSimonian and Laird method—frequently used as the default method for meta…

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