Methods to assess beta cell death mediated by cytotoxic T lymphocytes.

  title={Methods to assess beta cell death mediated by cytotoxic T lymphocytes.},
  author={Jing Chun Chen and Scott S. Grieshaber and Clayton E Mathews},
  journal={Journal of visualized experiments : JoVE},
Type 1 diabetes (T1D) is a T cell mediated autoimmune disease. During the pathogenesis, patients become progressively more insulinopenic as insulin production is lost, presumably this results from the destruction of pancreatic beta cells by T cells. Understanding the mechanisms of beta cell death during the development of T1D will provide insights to generate an effective cure for this disease. Cell-mediated lymphocytotoxicity (CML) assays have historically used the radionuclide Chromium 51… CONTINUE READING
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