Methods of molecular analysis: mutation detection in solid tumours.

@article{Frayling2002MethodsOM,
  title={Methods of molecular analysis: mutation detection in solid tumours.},
  author={Ian M Frayling},
  journal={Molecular pathology : MP},
  year={2002},
  volume={55 2},
  pages={73-9}
}
Most mutation detection techniques are unsuitable for routine use on solid tumours. Important parameters include sensitivity, specificity, efficiency, use of existing resources, and cost. In the UK, < 0.2% of service genetics laboratory activity involves mutation analysis in tumours (usually for family studies), mainly because it is time consuming/labour intensive (thus expensive) and DNA extracted from formalin fixed, paraffin wax embedded tissue is of low quality and yield. The small size of… CONTINUE READING
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