Methods of assessment used in ankylosing spondylitis clinical trials: a review.

@article{Laurent1991MethodsOA,
  title={Methods of assessment used in ankylosing spondylitis clinical trials: a review.},
  author={Michael Laurent and Walter Buchanan and Nicholas Bellamy},
  journal={British journal of rheumatology},
  year={1991},
  volume={30 5},
  pages={326-9}
}
Twenty non-steroidal anti-inflammatory drug (NSAID) trials in ankylosing spondylitis (AS) were reviewed to assess the frequency with which statistically significant differences had been detected between active drug and either a placebo or an NSAID-free washout period. Differences in pain severity were almost invariability detected, irrespective of the scale employed. In contrast, significant differences in axial movement were rarely detected in placebo controlled studies, and only about half of… CONTINUE READING

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