Methods for the monitoring of direct thrombin inhibitors.

  title={Methods for the monitoring of direct thrombin inhibitors.},
  author={Gerd Hafner and Markus Roser and Matthias Nauck},
  journal={Seminars in thrombosis and hemostasis},
  volume={28 5},
Direct thrombin inhibitors are available for prophylactic as well as therapeutic purposes. Application of hirudin in therapeutic doses has been shown to require drug monitoring. Currently, most experience is available for recombinant hirudin, but the principle aspects of drug monitoring are the same for all direct thrombin inhibitors. Most frequently, activated partial thromboplastin time (aPTT) and modifications of the activated clotting time (ACT) have been used for the monitoring of hirudin… CONTINUE READING


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