Methods for the analysis of inositol phosphates.

  title={Methods for the analysis of inositol phosphates.},
  author={Nicolas M. Dean and Michael A. Beaven},
  journal={Analytical biochemistry},
  volume={183 2},
Interest in the inositol phospholipids was stimulated by the simultaneous discoveries that the products of hydrolysis of these lipids could serve as messengers to activate to synergistic signaling pathways in hormonally responsive cells, namely, inositol 1,4,5-trisphosphate which causes the release of Ca2+ from intracellular stores and diacylglycerol which promotes the activation of protein kinase C. At the same time, Berridge and co-workers introduced relatively simple approaches to study the… CONTINUE READING
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