Methods for quantitative evaluation of alveolar structure during in vivo microscopy.

@article{Czaplik2011MethodsFQ,
  title={Methods for quantitative evaluation of alveolar structure during in vivo microscopy.},
  author={Michael Czaplik and Rolf Rossaint and Edmund Koch and Astrid V. Fahlenkamp and Wolfgang Schroeder and Paolo Pelosi and Wolfgang Michael Kuebler and Johannes Bickenbach},
  journal={Respiratory physiology & neurobiology},
  year={2011},
  volume={176 3},
  pages={123-9}
}
In vivo fibred confocal laser scanning microscopy allows an evaluation of differences in alveolar mechanics between healthy and acutely injured lungs during mechanical ventilation. The aim of this study was to develop new methods for a quantitative analysis of microscopic images in a murine model of experimental acute lung injury (ALI) and to assess the methods' portability to a large animal model. Differences observed in ALI compared to healthy lungs were: reduction of air-filled areas… CONTINUE READING